Ganong's Review of Medical Physiology 26th edition Pdf

Ganong’s Review of Medical Physiology 26th edition Pdf Free

Ganong’s Review of Medical Physiology 26th edition pdf free has helped medical professionals understand human and mammalian physiology. Applauded for its engaging and engaging writing style, Ganong’s concisely covers all important topics without sacrificing depth or readability and offers more detailed and high-yielding information per page than any other similar text or review. Fully updated to reflect the latest research and developments in important areas such as chronic pain, reproductive physiology, and acid-base homeostasis, Ganong’s Review of Medical Physiology, 26th Edition incorporates examples from clinical medicine to illustrate important physiological concepts. Ganong’s will prove valuable to students who need a concise review for the USMLE or to clinicians who want to keep up with the changing world of medical physiology. You can download this medical physiology book with a direct download.

The study of physiological system structure and function, as well as pathophysiological alterations, has its foundations in physical and chemical laws and the molecular and cellular makeup of each tissue and organ system. Ganong’s Review of Medical Physiology is structured into seven sections. This first section provides an overview of the basic building blocks or bases that provide the important framework for human physiology. It is important to note here that the seven chapters in this initial section are not meant to provide an exhaustive understanding of biophysics, biochemistry, or cellular and molecular physiology; rather, they are to serve as a reminder of how the basic principles from these disciplines contribute to medical physiology discussed in later sections associated with physiological functions of organs and systems.



Book Name Ganong’s Review of Medical Physiology
Author of Book Kim Barrett, Susan Barman, Jason Yuan , Heddwen Brooks 
Edition 26th
Language English
Format PDF
Category Medical Physiology



In the first two chapters of Ganong’s Review of Medical Physiology 26th edition Pdf Free this section, the following basic components are presented and discussed: electrolytes; carbohydrates, lipids and fatty acids; amino acids and proteins; and nucleic acids. Students are reminded of some of the basic principles and building blocks of biophysics and biochemistry and how they fit into the physiological environment. Examples of direct clinical applications are provided in the clinical boxes to help bridge the gap between the basic principles and functions of human cells, tissues and organs. These basic principles are followed with a discussion of the generic cell and its components. It is important to realize that the cell is the basic functional unit within the body, and it is the collection and fine-tuned interactions between these fundamental units that allow the proper function of tissues, organs, and organisms.



Topics of this Edition:

Ganong’s Review of Medical Physiology has the following topics in this 26th Edition 

Section I Cellular Molecular Basis for Medical Physiology
1 General Principles Energy Production in Medical Physiology
2 Overview of Cellular Physiology
3 Immunity, Infection, Inflammation
4 Excitable Tissue: Nerve
5 Excitable Tissue: Muscle
6 Synaptic Junctional Transmission
7 Neurotransmitters Neuromodulators
Section II Central Peripheral Neurophysiology
8 Somatosensory Neurotransmission: Touch, Pain, Temperature
9 Smell Taste
10 Vision
11 Hearing Equilibrium
12 Reflex Voluntary Control of Posture Movement
13 Autonomic Nervous System
14 Electrical Activity of the Brain, SleepWake States, Circadian Rhythms
15 Learning, Memory, Language, Speech
Section III Endocrine Reproductive Physiology
16 Basic Concepts of Endocrine Regulation
17 Hypothalamic Regulation of Hormonal Functions
18 The Pituitary Gland
19 The Adrenal Medulla Adrenal Cortex
20 The Thyroid Gland
21 Hormonal Control of Calcium Phosphate Metabolism the Physiology of Bone
22 Reproductive Development Function of the Female Reproductive System
23 Function of the Male Reproductive System
24 Endocrine Functions of the Pancreas Regulation of Carbohydrate Metabolism
Section IV Gastrointestinal Physiology
25 Overview of Gastrointestinal Function Regulation
26 Digestion Absorption of Nutrients
27 Gastrointestinal Motility
28 Transport Metabolic Functions of the Liver
Section V Cardiovascular Physiology
29 Origin of the Heartbeat the Electrical Activity of the Heart
30 The Heart as a Pump
31 Blood as a Circulatory Fluid the Dynamics of Blood Lymph Flow
32 Cardiovascular Regulatory Mechanisms
33 Circulation Through Special Regions
Section VI Respiratory Physiology
34 Introduction to Pulmonary Structure Mechanics
35 Gas Transport pH
36 Regulation of Respiration
Section VII Renal Physiology
37 Renal Function Micturition
38 Regulation of Extracellular Fluid Composition Volume
39 Acidification of the Urine Bicarbonate Excretion
Answers to Multiple Choice Questions

What is in this Edition:

Fully updated to reflect the latest research and developments in important areas such as chronic pain, reproductive physiology, and acid-base homeostasis, Ganong’s Journal of Medical Physiology, 26th Edition incorporates examples from clinical medicine to illustrate important physiological concepts. Ganongs will prove valuable to students who need a concise review for the USMLE, or to clinicians who want to keep up with the changing world of medical physiology.

  • More than 600 full-color illustrations
  • Two types of review questions: end-of-chapter and board-style
  • NEW! Increased number of clinical cases and flow charts
  • NEW! Video tutorials from the author; high-yield Frequently Asked Question feature with detailed explanations; improved legends that eliminate the need to refer back to the text 

This book is one of the best medical books on the subject of physiology and its importance can be understood by the fact that this is the 26th edition of it. This edition has all the updated information for the subject and contains sharper images than previous versions. Ganong’s physiology is known worldwide for its popularity and trust. Many medical students rely on him annually for exams and teachers. You can also use it during your USMLE exams.


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Functional Morphology Of The Cell And Homeostasis

The actual environment of the cells of the body is the interstitial component of the extracellular fluid (ECF). Because normal cell function depends on the constancy of this fluid, it is not surprising that in multicellular animals, an immense number of regulatory mechanisms have evolved to maintain it. To describe “the various physiologic arrangements which serve to restore the normal state, once it has been disturbed,” W.B. Cannon coined the term homeostasis. The buffering properties of the body fluids and the renal and respiratory adjustments to the presence of excess acid or alkali are examples of homeostatic mechanisms. There are countless other examples, and a large part of physiology is concerned with regulatory mechanisms that act to maintain the constancy of the internal environment.

Many of these regulatory mechanisms operate on the principle of negative feedback; deviations from a given normal set point are detected by a sensor, and signals from the sensor trigger compensatory changes that continue until the setpoint are again reached. Basic knowledge of cell function and structure is essential to an understanding of homeostasis, the organ systems and the way they function in the body. A key tool for examining cellular constituents is the microscope. A light microscope can resolve structures as close as 0.2 µm, while an electron microscope can resolve structures as close as 0.002 µm. Although cell dimensions are quite variable, this resolution can provide a good look at the inner workings of the cell. The advent of common access to phase contrast, fluorescent, confocal, and many other microscopy techniques along with specialized probes for both static and dynamic cellular structures further expanded the examination of cell structure and function.


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The membrane that surrounds the cell is a remarkable structure. It is composed of lipids and proteins and is semi-permeable, allowing the passage of some substances and excluding others. However, its permeability can also vary because it contains numerous regulated ion channels and other transport proteins that can change the number of substances that move through it. It is generally known as the plasma membrane. The nucleus and other organelles of the cell are linked by similar membranous structures. Although the chemical structures of membranes and their properties vary considerably from place to place, they have certain common characteristics. They are generally about 7.5 nm (75 angstroms [Å]) thick.

The main lipids are phospholipids such as phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine. The shape of the phospholipid molecule reflects its solubility properties: the “head” end of the molecule contains the phosphate portion and is relatively soluble in water (polar, hydrophilic) and the “tail” ends are relatively insoluble (nonpolar, hydrophobe). Possession of both hydrophilic and hydrophobic properties makes the lipid an amphipathic molecule. In the membrane, the hydrophilic ends of the molecules are exposed to the aqueous environment that bathes the exterior of the cells and the aqueous cytoplasm; the hydrophobic ends are found on the water-poor interior of the membrane. In prokaryotes (that is, bacteria in which there is no nucleus), the membranes are relatively simple, but in eukaryotes (that is, cells that contain nuclei), the cell membranes contain various glycosphingolipids, sphingomyelin, and cholesterol, in addition to phospholipids and phosphatidylcholine.

Organization of the phospholipid bilayer

FIGURE 2–2 Organization of the phospholipid bilayer and associated proteins in a biologic membrane. The phospholipid molecules that make up the membrane each have two hydrophobic fatty acid chains attached to a hydrophilic phosphate head. Individual proteins take on different shapes and positions in the cell. Many are integral proteins, extending into the membrane or peripheral proteins that are attached to the inside or outside (not shown) of the membrane. Proteins can be modified (e.g, with carbohydrate chains). Many specific protein attachments and cholesterol that are commonly found in the bilayer are omitted for clarity. and associated proteins in a biological membrane.


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