Guyton hall 14th edition

Guyton & Hall 14th edition [PDF free download] Medical Physiology

In this post, you will be able to download the Textbook of Guyton and Hall Medical Physiology 14th Edition PDF free. This free medical book of Medical Physiology is available free with a direct download link. The Fourteenth Edition of the Guyton and Hall Medical Physiology Textbook by author John E. Hall Ph.D. and Michael E explains complex physiology concepts with a clear presentation at ease. A larger font size emphasizes basic information while supporting information, including clinical examples, is detailed in a smaller font and highlighted in pale blue, making it easier to quickly read essential text or search for a further study. This two-tone approach, along with other standout features, makes this best-selling text.

  • Clinically oriented perspective
  • Focuses on the core material
  • Presents information in short chapters
  • More than 1,200 full-color drawings and diagrams
  • Expanded clinical coverage


Book Name Guyton & Hall Medical Physiology
Author of Book John E. Hall, Michael E. Hal
Edition 14th
Language English
Format PDF
Category Guyton and Hall Books (click)



The first edition of the Medical Physiology Textbook was written by Arthur C. Guyton almost 50 years ago. Unlike many major medical textbooks, which often have 20 or more authors, the first eight editions of the Medical Physiology Textbook were written entirely by Dr. Guyton with each new edition arriving on schedule for almost 40 years. Over the years, Dr. Guyton’s textbook was widely used around the world and translated into 13 languages. One of the main reasons for the book’s unprecedented success was its amazing ability to explain complex physiological principles in language easily understood by students. His main goal with each issue was to instruct students in physiology, not to impress his professional colleagues. Textbook of Guyton and Hall Medical Physiology 11th Edition PDF free written by  John E. Hall.

Arthur C. Guyton’s writing style always kept the tone of a teacher talking to his students. I had the privilege of working closely with Dr. Guyton for almost 30 years and the honor of helping him with the ninth and tenth editions. For the eleventh edition, I have the same goal as in previous editions: to explain, in language easily understood by students, how the different cells, tissues, and organs of the human body work together to sustain life. This task has been challenging and exciting because our growing knowledge of physiology continues to unravel new mysteries of bodily functions. Many new techniques have been developed for learning about molecular and cellular physiology. We can increasingly present the principles of physiology in the terminology of the physical and molecular sciences rather than simply in a series of separate and inexplicable biological phenomena. This change is welcome, but it also makes reviewing each chapter a must, grasp a need. In this edition, I have tried to maintain the same unified organization of the text that has been helpful to students in the past and to ensure that the book is comprehensive enough that students wish to use it in later life as a basis for their professional studies careers. I hope this textbook conveys the majesty of the human body and its many functions and encourages students to study physiology throughout their careers.

Physiology is the link between basic science and medicine. The great beauty of physiology is that it integrates the individual functions of all the different cells, tissues, and organs of the body into one functional whole, the human body. In fact, the human body is much more than the sum of its parts, and life is based on this total function, not just the function of individual parts of the body isolated from each other. This brings us to an important question: How do the separate organs and systems coordinate to keep the entire body functioning properly? Fortunately, our bodies are endowed with a vast network of feedback controls that strike the necessary balances without which we could not live. Physiologists call this high level of internal body control homeostasis. In disease states, functional balances are often seriously disturbed and homeostasis is impaired. And, when even a single disturbance reaches a limit, the whole body can no longer live. One of the objectives of this text, therefore, is to emphasize the effectiveness and beauty of the body’s homeostasis mechanisms, as well as to present their abnormal function in disease.


Topics of this Edition:

14th Edition of Guyton and Hall Medical Physiology contains the following chapters in this version.

1 – Functional Organization of the Human Body and Control of the “Internal Environment”
2 – The Cell and Its Functions
3 – Genetic Control of Protein Synthesis, Cell Function, and Cell Reproduction
4 – Transport of Substances Through Cell Membranes
5 – Membrane Potentials and Action Potentials
6 – Contraction of Skeletal Muscle
7 – Excitation of Skeletal Muscle: Neuromuscular Transmission and Excitation-­Contraction Coupling
8 – Excitation and Contraction of Smooth Muscle
9 – Cardiac Muscle; The Heart as a Pump and Function of the Heart Valves
10 – Rhythmical Excitation of the Heart
11 – Fundamentals of Electrocardiography
12 – Electrocardiographic Interpretation of Cardiac Muscle and Coronary Blood Flow Abnormalities: Vectorial Analysis
13 – Cardiac Arrhythmias and Their Electrocardiographic Interpretation
14 – Overview of the Circulation: Pressure, Flow, and Resistance
15 – Vascular Distensibility and Functions of the Arterial and Venous Systems
16 – The Microcirculation and Lymphatic System: Capillary Fluid Exchange, Interstitial Fluid, and Lymph Flow
17 – Local and Humoral Control of Tissue Blood Flow
18 – Nervous Regulation of the Circulation and Rapid Control of Arterial Pressure
19 – Role of the Kidneys in Long-­Term Control of Arterial Pressure and in Hypertension: The ­Integrated System for Arterial Pressure Regulation
20 – Cardiac Output, Venous Return, and Their Regulation
21 – Muscle Blood Flow and Cardiac Output ­During Exercise; the Coronary Circulation and Ischemic Heart Disease
22 – Cardiac Failure
23 – Heart Valves and Heart Sounds; Valvular and Congenital Heart Defects
24 – Circulatory Shock and Its Treatment
25 – Regulation of Body Fluid Compartments: Extracellular and Intracellular Fluids; Edema
26 – The Urinary System: Functional Anatomy and Urine Formation by the Kidneys
27 – Glomerular Filtration, Renal Blood Flow, and Their Control
28 – Renal Tubular Reabsorption and Secretion
29 – Urine Concentration and Dilution; Regulation of Extracellular Fluid Osmolarity and Sodium Concentration
30 – Renal Regulation of Potassium, Calcium, Phosphate, and Magnesium; Integration of Renal Mechanisms for Control of Blood Volume and Extracellular Fluid Volume
31 – Acid–Base Regulation
32 – Diuretics and Kidney Diseases
33 – Red Blood Cells, Anemia, and Polycythemia
34 – Resistance of the Body to Infection: I. Leukocytes, Granulocytes, the Monocyte-­Macrophage System, and Inflammation
35 – Resistance of the Body to Infection: II. Immunity and Allergy
36 – Blood Types; Transfusion; and Tissue and Organ Transplantation
37 – Hemostasis and Blood Coagulation
38 – Pulmonary Ventilation
39 – Pulmonary Circulation, Pulmonary Edema, and Pleural Fluid
40 – Principles of Gas Exchange; Diffusion of Oxygen and Carbon Dioxide Through the Respiratory Membrane
41 – Transport of Oxygen and Carbon Dioxide in Blood and Tissue Fluids
42 – Regulation of Respiration
43 – Respiratory Insufficiency—Pathophysiology, Diagnosis, Oxygen Therapy
44 – Aviation, High Altitude, and Space Physiology
45 – Physiology of Deep-­Sea Diving and Other Hyperbaric Conditions
46 – Organization of the Nervous System, Basic Functions of Synapses, and Neurotransmitters
47 – Sensory Receptors, Neuronal Circuits for Processing Information
48 – Somatic Sensations: I. General Organization, Tactile and Position Senses
49 – Somatic Sensations: II. Pain, Headache, and Thermal Sensations
50 – The Eye: I. Optics of Vision
51 – The Eye: II. Receptor and Neural Function of the Retina
52 – The Eye: III. Central Neurophysiology of Vision
53 – The Sense of Hearing
54 – The Chemical Senses—Taste and Smell
55 – Spinal Cord Motor Functions; the Cord Reflexes
56 – Cortical and Brain Stem Control of Motor Function
57 – Cerebellum and Basal Ganglia Contributions to Overall Motor Control
58 – Cerebral Cortex, Intellectual Functions of the Brain, Learning, and Memory
59 – The Limbic System and the Hypothalamus—Behavioral and Motivational Mechanisms of the Brain
60 – States of Brain Activity—Sleep, Brain Waves, Epilepsy, Psychoses, and Dementia
61 – The Autonomic Nervous System and the Adrenal Medulla
62 – Cerebral Blood Flow, Cerebrospinal Fluid, and Brain Metabolism
63 – General Principles of Gastrointestinal Function—Motility, Nervous Control, and Blood Circulation
64 – Propulsion and Mixing of Food in the Alimentary Tract
65 – Secretory Functions of the Alimentary Tract
66 – Digestion and Absorption in the Gastrointestinal Tract
67 – Physiology of Gastrointestinal Disorders
68 – Metabolism of Carbohydrates and Formation of Adenosine Triphosphate
69 – Lipid Metabolism
70 – Protein Metabolism
71 – The Liver
72 – Dietary Balances; Regulation of Feeding; Obesity and Starvation; Vitamins and Minerals
73 – Energetics and Metabolic Rate
74 – Body Temperature Regulation and Fever
75 – Introduction to Endocrinology
76 – Pituitary Hormones and Their Control by the Hypothalamus
77 – Thyroid Metabolic Hormones
78 – Adrenocortical Hormones
79 – Insulin, Glucagon, and Diabetes Mellitus
80 – Parathyroid Hormone, Calcitonin, ­Calcium and Phosphate Metabolism, ­Vitamin D, Bone, and Teeth
81 – Reproductive and Hormonal Functions of the Male (and Function of the Pineal Gland)
82 – Female Physiology Before Pregnancy and Female Hormones
83 – Pregnancy and Lactation
84 – Fetal and Neonatal Physiology
85 – Sports Physiology
Normal Values for Selected Common Laboratory Measurements

Demo Content:

You can read example content of Guyton & Hall 14th edition Medical Physiology pdf free

Fundamentals of Electrocardiography

When a cardiac impulse passes through the heart, an electrical current also spreads from the heart into the adjacent tissues surrounding the heart. A small portion of the current spreads all the way to the surface of the body. If electrodes are placed on the skin on opposite sides of the heart, electrical potentials generated by the current can be recorded; the recording is known as an electrocardiogram (ECG).

 A normal ECG for two beats

A normal ECG for two beats of the heart is shown in Figure 11-1.


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Waveforms of The Normal Electrocardiogram

The normal ECG (see Figure 11-1) is composed of a P wave, a QRS complex, and a T wave. The QRS complex is often, but not always, three separate waves: the Q wave, the R wave, and the S wave. The P wave is caused by electrical potentials generated when the atria depolarize before an atrial contraction begins. The QRS complex is caused by potentials generated when the ventricles depolarize before contraction—that is, as the depolarization wave spreads through the ventricles. Therefore, both the P wave and the components of the QRS complex are depolarization waves. The T wave is caused by potentials generated as the ventricles recover from depolarization. This process normally occurs in ventricular muscle 0.25 to 0.35 seconds after depolarization. The T wave is known as a repolarization wave. Thus, the ECG is composed of both depolarization and repolarization waves. The principles of depolarization and repolarization are discussed in Chapter 5. The distinction between depolarization waves and repolarization waves is so important in electrocardiography that further clarification is necessary.

Cardiac Depolarization Waves Versus Repolarization Waves

Figure 11-2 shows a single cardiac muscle fiber in four stages of depolarization and repolarization, with the color red designating depolarization. During depolarization, the normal negative potential inside the fiber reverses and becomes slightly positive inside and negative outside.

In Figure 11-2A, depolarization, demonstrated by red positive charges inside and red negative charges outside, is traveling from left to right. The first half of the fiber has already depolarized while the remaining half is still polarized. Therefore, the left electrode on the outside of the fiber is in an area of negativity, and the right electrode is in an area of positivity, which causes the meter to record positively. To the right of the muscle fiber is shown a record of changes in potential between the two electrodes, as recorded by a highspeed recording meter. Note that when depolarization has reached the halfway mark in Figure 11-2A, the recording on the right has risen to a maximum positive value. In Figure 11-2B, depolarization has extended over the entire muscle fiber, and the recording to the right has returned to the zero baselines because both electrodes are now in areas of equal negativity. The completed wave is a depolarization wave because it results from the spread of depolarization along the muscle fiber membrane. Figure 11-2C shows halfway repolarization of the same muscle fiber, with positivity returning to the outside of the fiber. At this point, the left electrode is in an area of positivity, and the right electrode is in an area of negativity. This polarity is opposite to the polarity in Figure 11- 2A. Consequently, the recording, as shown to the right, becomes negative. In Figure 11-2D, the muscle fiber has completely repolarized, and both electrodes are now in areas of positivity so that no potential difference is recorded between them. Thus, in the recording on the right, the potential returns once more to zero. This completed negative wave is a repolarization wave because it results from the spread of repolarization along the muscle fiber membrane.

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