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Table of Contents
Description:
| Book Name | Physeo Immunology |
| Author of Book | Travis Norseth, Michael Christensen, & Rhett Thomson |
| Edition | 1st |
| Language | English |
| Format | |
| Price | PDF free |
Topics:
Here are the topics of Physeo Immunology Free PDF
IMMUNOLOGY
Section I – Lymphoid Structures
Section II – Acute Inflammation
Section III – Neutrophils
Section IV – Kinin
Section V – Complement
Section VI – Chronic Inflammation
Section VII – Major Histocompatibility Complexes
Section VIII – Macrophages
Section VIII.1 – Cytokines from Macrophages and Dendritic Cells
Section IX – NK Cells and Cytotoxic T Cells
Section X – Positive and Negative Selection
Section XI – T-cell Activation and Subtypes
Section XI.1 – Cytokines from Th1 and NK Cells
Section XI.2 – Cytokines from Th2 Cells
Section XI.3 – Cytokines from Th17 Cells
Section XI.4 – Cytokines from Treg Cells
Section XII – Antibodies
Section XIII – B-cells
Section XIV – Vaccinations
Section XV – Hypersensitivity Reactions
Section XVI – Blood Transfusion Reactions
Section XVII – Transplant Rejection
IMMUNODEFICIENCIES
Section I – Bruton Agammaglobulinemia
Section II – Selective IgA Deficiency
Section III – Common Variable Immunodeficiency (CVID)
Section IV – Thymic Aplasia
Section V – IL-12 Receptor Deficiency
Section VI – Job Syndrome
Section VII – Chronic mucocutaneous candidiasis
Section VIII – Severe combined immunodeficiency (SCID)
Section IX – Ataxia-telangiectasia
Section X – Hyper-IgM syndrome
Section XI – Wiskott-Aldrich Syndrome
Section XII – Leukocyte Adhesion Deficiency
Section XIII – Chediak-Higashi syndrome
Section XIV – Chronic Granulomatous Disease
REVIEW QUESTIONS
The neutrophils in a patient are able to roll along the vascular wall through weak interactions. However, there is a protein deficiency on neutrophils that prevents them from tightly binding to endothelial cells. As a result, the neutrophils continue rolling along the vascular wall without stopping at the site of inflammation. What protein is likely deficient?
Correct answer: LFA-1 (CD18)
The question is focused on neutrophil extravasation
• Apparently the neutrophils do a fine job performing those weak interactions with the endothelial cells → margination and rolling intact
• The inability to tightly bind (adhere) to vascular wall indicates adhesion dysfunction (LFA-1/CD18 on neutrophils vs. ICAM and VCAM on endothelial cells)
• Note: If you thought the answer was PECAM-1, you likely understand the process of extravasation. However, before the neutrophil can utilize PECAM-1 and transmigrate to the inflamed tissue, it must first adhere to the vascular wall. If the neutrophils continue rolling without stopping, we
assume they were never able to adhere.
2nd REVIEW QUESTIONS
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