Physeo Immunology Free PDF 2021

Physeo Immunology Free PDF Medical Course and Step 1 review 2021

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Book Name  Physeo Immunology
Author of Book Travis Norseth, Michael Christensen, & Rhett Thomson
Edition 1st
Language English
Format PDF
Price PDF free 




Here are the topics of Physeo Immunology Free PDF 


Section I – Lymphoid Structures

Section II – Acute Inflammation

Section III – Neutrophils 

Section IV – Kinin

Section V – Complement

Section VI – Chronic Inflammation

Section VII – Major Histocompatibility Complexes

Section VIII – Macrophages

Section VIII.1 – Cytokines from Macrophages and Dendritic Cells

Section IX – NK Cells and Cytotoxic T Cells

Section X – Positive and Negative Selection 

Section XI – T-cell Activation and Subtypes

Section XI.1 – Cytokines from Th1 and NK Cells

Section XI.2 – Cytokines from Th2 Cells 

Section XI.3 – Cytokines from Th17 Cells 

Section XI.4 – Cytokines from Treg Cells 

Section XII – Antibodies 

Section XIII – B-cells

Section XIV – Vaccinations

Section XV – Hypersensitivity Reactions

Section XVI – Blood Transfusion Reactions

Section XVII – Transplant Rejection



Section I – Bruton Agammaglobulinemia 

Section II – Selective IgA Deficiency

Section III – Common Variable Immunodeficiency (CVID)

Section IV – Thymic Aplasia

Section V – IL-12 Receptor Deficiency

Section VI – Job Syndrome 


Section VII – Chronic mucocutaneous candidiasis

Section VIII – Severe combined immunodeficiency (SCID)

Section IX – Ataxia-telangiectasia 

Section X – Hyper-IgM syndrome 

Section XI – Wiskott-Aldrich Syndrome

Section XII – Leukocyte Adhesion Deficiency 

Section XIII – Chediak-Higashi syndrome 

Section XIV – Chronic Granulomatous Disease 

The lymphatic system
The lymphatic system





The neutrophils in a patient are able to roll along the vascular wall through weak interactions. However, there is a protein deficiency on neutrophils that prevents them from tightly binding to endothelial cells. As a result, the neutrophils continue rolling along the vascular wall without stopping at the site of inflammation. What protein is likely deficient?

Myeloperoxidase (MPO)

Correct answer: LFA-1 (CD18)

The question is focused on neutrophil extravasation

• Apparently the neutrophils do a fine job performing those weak interactions with the endothelial cells → margination and rolling intact

• The inability to tightly bind (adhere) to vascular wall indicates adhesion dysfunction (LFA-1/CD18 on neutrophils vs. ICAM and VCAM on endothelial cells)

• Note: If you thought the answer was PECAM-1, you likely understand the process of extravasation. However, before the neutrophil can utilize PECAM-1 and transmigrate to the inflamed tissue, it must first adhere to the vascular wall. If the neutrophils continue rolling without stopping, we
assume they were never able to adhere.



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