Practical Lymph Node and Bone Marrow Pathology PDF free. Among the subspecialties of surgical pathology, hematopathology occupies a rather unique place due to the convergence of histopathology and cytopathology, particularly when diagnosing conditions involving the bone marrow, and the growing repertoire of auxiliary diagnostic and prognostic tests. . Hematopathology was an early adopter of immunological and molecular techniques and continues to embrace advances in ancillary testing modalities. The diagnostic certainty offered by the objective results obtained from the ancillary studies attracts some pathologists (including ourselves) to this field. Paradoxically, it is also the reason that many surgical pathologists avoid hematopathology.
The multi-pronged approach to the classification of hematopoietic and lymphoid neoplasms, combining morphology, immunophenotype, molecular genetic and cytogenetic findings, and clinical features advocated in the Revised European and American Lymphoma Classification (REAL) (1993), was more successful in predicting results in each entity compared to its predecessors. The success of the REAL classification led to the WHO (2001) classification based on the same principles, which also incorporated the classification of myeloid neoplasms. The WHO classification has gained worldwide recognition as the classification of hematolymphoid neoplasia. The recognition of subtle differences in the immunophenotypic, molecular and biological properties of previously recognized entities that dictate optimal therapy and/or outcome, was used to subdivide some common entities, in the second edition published in 2008 and even more so in the recently published review. . in 2017 *. This book essentially follows this recent revision of the WHO classification, but the material is organized in a way that will be most useful to a practicing surgical pathologist. This is accomplished by focusing on morphological findings as a starting point. Using this morphological “spine” and several frequently asked questions (FAQs), the reader is guided to a list of differential diagnoses and a rational final diagnosis.
|Book Name||Practical Lymph Node and Bone Marrow Pathology|
|Author of Book||Endi Wang, Anand Shreeram Lagoo|
This book provides a practically applicable, step-by-step approach to the accurate and clinically relevant diagnosis of lymph node (LN) and bone marrow (MO) biopsies.
Physicians await pathological guidance not only with an accurate diagnosis, but also on disease progression, minimal residual disease, disease susceptibility to a particular therapy, the effects of prior therapy on prognosis, and subsequent therapy. , etc.
This book provides a brief but accurate guide to the prognosis and therapeutic implications of the key ancillary studies so that the pathologist is comfortable answering the physician’s questions about the full range of manifestations and management of the disease.
The text essentially follows the WHO (2016) classification, but the material is organized in the most useful way for a practicing surgical pathologist. This is accomplished by focusing on morphological findings as a starting point. Using this morphological “spine” and several frequently asked questions (FAQs), the reader is guided to a rational list of differential diagnoses that lead to a definitive diagnosis. The contents of each chapter are carefully selected so that practically important and directly applicable information is available in an easy to find and understand format.
Topics of this Edition:
1: Essentials of the Immune Response and Immunophenotyping
2: Molecular Genetics and Cell Biology for Hematopathology
3: Evaluation of Excised Lymph Nodes
4: Lymphoid Pathology on Small Biopsies (FNA and Small Core) – Advantages and Limitations: Guidelines for Ancillary Studies According to Clinical Scenario and Morphology
5: Small B-Cell Lymphomas With and Without Plasmacytic Differentiation
6: Large B-Cell Lymphoma
7: High-Grade B-Cell Lymphoma
8: Major Subtypes of Mature T- and NK-Cell Neoplasms
9: Hodgkin Lymphomas
10: Posttransplant Lymphoproliferative Disorders (PTLDs)
11: Immunodeficiency-Associated Lymphoproliferative Disorders Other Than PTLD (in Primary Immune Deficiency, HIV, and Iatrogenic Conditions)
12: Primary Extranodal Lymphomas of the GI Tract, Lung, CNS, and Skin with Common Mimics
13: Lymphoid Neoplasms with “Benign” Clinical Course or Unclear Malignant Potential
14: B-Cell Lymphoma in Children or Pediatric Type
15: Indolent T-/NK-Cell Lymphoproliferative Disorders
16: Composite Lymphoma
17: Histiocytic/Dendritic Cell Neoplasms: Primary and Transdifferentiated
18: Typical Morphologic Patterns of Infectious and Other Reactive Lymphadenopathies
19: HHV8-Associated Lymphoproliferative Disorders
20: Bone Marrow at Initial Diagnosis: Clinical Associations and Approach to Diagnosis
21: Acute Leukemias
22: Chronic Myeloid Leukemia
23: Chronic Myeloproliferative Neoplasms (Other Than Chronic Myeloid Leukemia)
24: Myelodysplastic Syndromes
25: Myelodysplastic/Myeloproliferative Neoplasms
26: Plasma Cell Neoplasms (Including Plasma Cell Myeloma)
27: Bone Marrow Involvement by Lymphoid Neoplasms
28: Bone Marrow Involvement by Metastases and Granulomatous Conditions
29: Bone Marrow Findings in Congenital/Hereditary Conditions
30: Bone Marrow Involvement by More Than One Entity of Hematolymphoid Neoplasm
31: Detection of Minimal Residual Disease
32: Therapy-Induced Marrow Changes
What are the major subtypes of myeloproliferative neoplasms (MPNs)?
- Major subtypes of myeloproliferative neoplasms according to the 2017 World Health Organization Classification
of Tumors of Hematopoietic and Lymphoid Tissues include:
– Chronic myeloid leukemia, BCR-ABL1 positive
– Chronic neutrophilic leukemia (CNL)
– Polycythemia vera (PV)
– Primary myelofibrosis (PMF) includes both profibrotic/early primary myelofibrosis and overt primary
– Essential thrombocythemia (ET)
– Chronic eosinophilic leukemia, not otherwise specified (CEL, NOS)
– Myeloproliferative neoplasm, unclassifiable (MPN-U)
- Mastocytosis and myeloid/lymphoid neoplasms with
eosinophilia and gene rearrangement are separate chapters of the 2017 WHO, but they are included here for
- CML is the most common subtype of MPN but is considered separately in Chap. 22 because its overall biology,
diagnosis, treatment, and clinical behavior are uniquely
connected to the presence of the BCR/ABL translocation.
What are the typical morphological findings in MPNs?
- Peripheral blood neutrophilia with ≥80% mature neutrophils and bands, only rare blasts, and <10% early neutrophil
precursors is characteristic of CNL. Patients tend to have
splenomegaly often with accompanying hepatomegaly. The
bone marrow tends to be hypercellular with an elevated M: E
ratio. Blasts are not increased above 5% and dyspoiesis is
absent. The proliferation of megakaryocytes and erythrocytes
may be seen, but a neutrophilic predominance is essential.
- CNL is extremely rare, and a reactive leukemoid reaction
will show significant laboratory and morphological overlap. A recently discovered mutation in CSF3R gene can
assist in diagnosis.
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