Werner and Ingbar's the thyroid 11th Edition Free PDF Download

Werner and Ingbar’s the Thyroid 11th Edition Free PDF Download

Through ten great editions, Werner & Ingbars The Thyroid: A Fundamental and Clinical Text has been the go-to reference for the maximum complete insurance of the thyroid, consisting of anatomy, development, biochemistry, physiology, pathophysiology, and remedy of all thyroid problems. Now in complete shadeation during, the eleventh Edition of this award-prevailing textual content stays the clinician’s favored supply of authoritative records at the thyroid—an critical aid for all endocrinologists and thyroid surgeons.
Includes thorough updates and new content material during the textual content, specifically on thyroid cytopathology, thyroid imaging, and centered remedy of thyroid most cancers in addition to a brand new complete-shadeation format.

Covers all factors of the thyroid, consisting of thyroid hormone synthesis and secretion, thyroid function, and problems inclusive of thyrotoxicosis, hypothyroidism, and most cancers.
Discusses surgical control of thyroid most cancers, thyroid disruptors, thyroid hormone analogs, thyroid dysfunction’s results on different organ systems, the getting older thyroid, subclinical hypothyroidism and hyperthyroidism, and thyroid disorder in pregnancy.
Features insights from worldwide experts, consisting of new editor Dr. Peter Kopp of Northwestern University’s Feinberg School of Medicine.


Werner and Ingbar’s the thyroid 11th Edition by Lewis E. Braverman MD Free PDF Download


Book Name The thyroid
Author of Book Lewis E. Braverman MD
Language English
Format PDF
Category Medical books


About Author:

Lewis E. Braverman MD
Professor of Medicine, Boston University School of Medicine; Chief, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston Medical Center, Boston, MA.



Topics of this Edition:

Chapter 1 The heritage of the thyroid: A brief history 1
Peter A. Kopp

chapter 2 Development and anatomy of the hypothalamic–pituitary–thyroid axis 9
Pilar Santisteban and Sabine Costagliola
B. Thyroid Hormone Synthesis and Secretion 39

chapter 3 Thyroid hormone synthesis: Thyroid iodide transport 39
Nancy Carrasco

chapter 4 Thyroid hormone synthesis 59
Peter A. Kopp
C. Peripheral Thyroid Hormone Binding and Metabolism 86

chapter 5 Thyroid hormone transport proteins 86
David Halsall and Carla Moran

chapter 6 Intracellular pathways of iodothyronine metabolism/implications of deiodination
for thyroid hormone action 97
Antonio C. Bianco and Brian W. Kim
D. Thyroid Hormone Action 128

chapter 7 Intracellular actions by thyroid hormones 128
Paul M. Yen, Gregory A. Brent, and Anthony N. Hollenberg

chapter 8 Thyroid hormone structure–function relationships 143
Riccardo Zucchi
E. Factors That Control Thyroid Function 157

chapter 9 Chemistry and biosynthesis of thyrotropin 157
Ronald N. Cohen, Anthony N. Hollenberg, and Fredric E. Wondisford

chapter 10 The thyrotropin receptor 174
Gilbert Vassart and Patrice Rodien

chapter 11 Aging and the thyroid 183
Anne R. Cappola

chapter 12 Effects of drugs on TSH secretion, thyroid hormones’ absorption, synthesis,
metabolism, and action 187
David H. Sarne

chapter 13 Thyroid disruptors 203
Angela M. Leung

chapter 14 Nonthyroidal illness syndrome 214
Anita Boelen, Lies Langouche, Wilmar Wiersinga, and Greet Van den Berghe

chapter 15 Iodine deficiency and excess, endemic cretinism 230
Michael B. Zimmermann and Weiping Tengxx Contents
section II
Assessment of Thyroid Structure and Function 259

chapter 16 Physical examination of the thyroid gland 259
James V. Hennessey and Jeffrey R. Garber

chapter 17 Laboratory measurement of thyroid-related hormones, proteins, and autoantibodies in serum 267
Ulla Feldt-Rasmussen

chapter 18 Nonisotopic thyroid imaging 300
Gilles Russ and Jung Hwan Baek

chapter 19 Thyroid radionuclide uptake and imaging studies 310
Daniel A. Pryma

chapter 20 Cytopathology of the thyroid gland 321
Zubair W. Baloch and Virginia A. Livolsi

chapter 21 Histopathology of the thyroid gland 332
Zubair W. Baloch and Virginia A. Livolsi


Thyroid Diseases: Thyrotoxicosis 353
A. Causes of Thyrotoxicosis 353

chapter 22 Pathogenesis of Graves disease 353
Terry F . Davies and Yaron Tomer

chapter 23 Thyrotropin-induced thyrotoxicosis 370
Paolo Beck-Peccoz, Andrea Lania, and Luca Persani

chapter 24 Toxic adenoma and toxic multinodular goiter 378
Ralf Paschke

chapter 25 Trophoblastic tumors 389
Jerome M. Hershman

chapter 26 Sporadic painless, painful subacute and acute infectious thyroiditis 395
Alan P . Farwell and Elizabeth N. Pearce

chapter 27 Thyrotoxicosis of extrathyroidal origin 414
Angela M. Leung
B. Organ System Manifestations 419

chapter 28 Overview of the clinical manifestations of thyrotoxicosis 419
Henry B. Burch

chapter 29 Ophthalmopathy 427
Luigi Bartalena

chapter 30 The cardiovascular system in thyrotoxicosis 438
Salman Razvi

chapter 31 Thyroid hormones in intermediary metabolism, thermogenesis, and obesity 446
Francesco S. Celi

chapter 32 The skeletal system in thyrotoxicosis 454
Bernard Freudenthal, Laura Watts, Graham R. Williams, and J. H. Duncan Bassett

chapter 33 Thyroid dermopathy and thyroid acropachy 463
Vahab Fatourechi

chapter 34 Psychiatric and cognitive effects of thyrotoxicosis 476
Mary H. Samuels and Kathryn G. Schuff

chapter 35 Thyrotoxic storm 482
Leonard Wartofsky and Kenneth D. Burman
C. Diagnosis and Management of Thyrotoxicosis 489

chapter 36 Diagnosis of thyrotoxicosis 489
Paul W. Ladenson
chapter 37 Treatment of thyrotoxicosis 495
David S. Cooper

chapter 38 Subclinical thyrotoxicosis 524
Kristien BoelaertContents xxi
section IV
Thyroid Diseases: Hypothyroidism 531
A. Causes of Hypothyroidism 531

chapter 39 Chronic autoimmune thyroiditis 531
Anthony P . Weetman

chapter 40 Genetic defects causing hypothyroidism 543
N. Schoenmakers

chapter 41 Primary hypothyroidism due to other causes 555
Caroline T. Nguyen and Peter A. Singer

chapter 42 Central hypothyroidism 566
Luca Persani and Paolo Beck-Peccoz
B. Organ System Manifestations of Hypothyroidism 575

chapter 43 Overview of the clinical manifestations of hypothyroidism 575
Michael T. McDermott

chapter 44 Hypothyroidism and the heart 584
Salman Razvi

chapter 45 The skeletal system in hypothyroidism 592
Laura Watts, Bernard Freudenthal, J.H. Duncan Bassett, and Graham R. Williams

chapter 46 Psychiatric and cognitive effects of hypothyroidism 599
Kathryn G. Schuff and Mary H. Samuels

chapter 47 Myxedema Coma 605
Kenneth D. Burman and Leonard Wartofsky
C. Management of Hypothyroidism 612

chapter 48 Diagnosis of hypothyroidism 612
Paul W. Ladenson

chapter 49 Treatment of hypothyroidism 618
Jacqueline Jonklaas

chapter 50 Subclinical hypothyroidism 635
Robin P . Peeters
section V
Thyroid Diseases: Nontoxic Diffuse and Multinodular Goiter 641

chapter 51 Multinodular goiter: pathogenesis and management 641
Steen Joop Bonnema and Laszlo Hegedüs

chapter 52 Clinical evaluation and management of thyroid nodules 660
Susan J. Mandel and Jill E. Langer
section VI
Thyroid Cancers 683

chapter 53 Carcinomas of follicular epithelium: epidemiology and pathogenesis 683
Arthur B. Schneider, Cari M. Kitahara, and Alina Brenner

chapter 54 Genomic landscapes of thyroid cancers of follicular cell derivation 709
David G. McFadden, Thomas Giordano, James A. Fagin, and Yuri Nikiforov

chapter 55 Carcinoma of the follicular epithelium: surgical therapy 723
David L. Steward and Julie A. Sosa

chapter 56 Staging and prognosis of differentiated thyroid cancer 733
Donald S.A. McLeod

chapter 57 Medical management of differentiated epithelial cell thyroid cancer 751
Sebastiano Filetti, R. Michael Tuttle, and Steven I. Sherman

chapter 58 Papillary microcarcinomas 776
Akira Miyauchi and Yasuhiro Ito

chapter 59 Medullary thyroid cancer 784
Andreas Machens, Dagmar Führer, and Henning Drallexxii Contents

chapter 60 Poorly differentiated thyroid cancer, anaplastic thyroid cancer, and miscellaneous tumors of the thyroid 796
Bryan R. Haugen, Keith C. Bible, and Robert C. Smallridge

chapter 61 Thyroid cancer in children 813
Catherine A. Dinauer, Emily R. Christison-Lagay, and Gary L. Francis
section VII
The Thyroid in Infancy and Childhood 839

chapter 62 The maturation of thyroid function in the fetus, in the perinatal period and during childhood 839 Gabor Szinnai and Michel Polak

chapter 63 Hypothyroidism in infants and children 855
Johnny Deladoëy, Julia von Oettingen, and Guy Van Vliet

chapter 64 Impaired sensitivity to thyroid hormone: defects of transport, metabolism, and action 868
Alexandra M. Dumitrescu, Manassawee Korwutthikulrangsri, and Samuel Refetoff

chapter 65 Hyperthyroidism in the neonate, child, and adolescent 908
Scott A. Rivkees
section VIII
Thyroid Disorders in Pregnancy and Postpartum 923

chapter 66 Thyroid disorders during preconception, pregnancy, and the postpartum period 923
Tim I.M. Korevaar and Elizabeth N. Pearce
Index 943

Physical examination of the thyroid gland

Traditionally, clinicians have correlated characteristic physical findings with
historical clues to synthesize a diagnosis. Much of what is reviewed in this
section about the physical examination of the thyroid gland was described
over a century ago. Yet despite advancements in imaging and laboratory
diagnostic techniques, physical examination of the thyroid continues to play a
critical role in the assessment of patients with thyroid disorders and should
not be viewed as a lost or unlearned art. The occurrence of goiter was widespread throughout the world and
documented in numerous paintings, sculptures, and medical texts (Fig. 1-1)
(5). It was, however, unknown that goiter was related to the thyroid gland and
iodine deficiency, or that the thyroid gland existed (6). The ancient Greeks
called the goitrous swelling in the neck a bronchocele (“tracheal outpouch”).
A drawing by Leonardo da Vinci from around 1500 is thought to be the first
illustration of a normal thyroid gland (Fig. 1-2) and Vesalius described it in
1543, although he used the term laryngeal glands for the entire organ that we
now know as the thyroid gland. The etymology of the word thyroid is derived
from the Greek word thureos, which designates an oblong shield. It was
introduced by Thomas Wharton in 1656 who named the thyroid gland after
the Greek for “shield-shaped”—not by virtue of its own shape, but because of
the shape of the nearby thyroid cartilage (7).
Although Paracelsus (around 1529) and Platter (in 1562) speculated on a
connection between goiter and cretinism (8), the function of the thyroid gland
remained unknown until the 19th century. The most commonly held theory
was that the thyroid regulates blood flow to the brain. Based on the concept
that illness is an imbalance of the four humors (blood, phlegm, bile, and
black bile), goiter was explained by an excess of phlegm.






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